A review on ischemic heart disease prediction frameworks using machine learning

Abstract

Ischemic heart disease (IHD) is a leading cause of mortality worldwide, calling for advanced predictive models for timely intervention. Current literature reviews on machine learning (ML)-based IHD prediction frameworks often focus on predictive accuracy but lack depth in areas like dataset diversity, model interpretability, and privacy considerations. Existing IHD prediction frameworks face limitations, including reliance on small, homogenous datasets, limited critical analysis, and issues with model transparency, reducing their clinical utility. This review addresses these gaps through a systematic, comparative analysis of popular ML models, such as random forest (RF) and support vector machines (SVM), noting their strengths and limitations. Key contributions include a qualitative examination of prevalent tools, datasets, and evaluation metrics, identification of gaps in dataset diversity and interpretability; and recommendations for improving model transparency and data privacy. Major findings reveal a trend toward ensemble models for accuracy but highlight the need for explainable artificial intelligence (AI) to support clinical decisions. Future directions include using federated learning to enhance data privacy, integrating unstructured data for comprehensive prediction, and advancing explainable AI to build trust among healthcare providers. By addressing these areas, this review aims to guide future research toward developing robust, transparent ML frameworks that can be more effectively deployed in clinical settings.